Title of article :
The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats
Author/Authors :
UÇMAKLI, Ergün Fatih University - Sema Training and Research Center - Department of Pathology, Turkey , ARMUTCU, Ferah Fatih University - Faculty of Medicine - Department of Biochemistry, Turkey , ÖZTÜRK, Alaattin Fatih University - Sema Training and Research Center - Department of Surgery Clinics, Turkey
Abstract :
Aim: To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats.Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue.Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls.Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.
Keywords :
Formaldehyde , nitric oxide , iNOS , rat liver
Journal title :
Turkish Journal of Medical Sciences (TJMS)
Journal title :
Turkish Journal of Medical Sciences (TJMS)
