The relationship between HLA-G levels and oxidative stress parameters in patients with breast cancer

Aim: To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P 0.001). While vitamin C levels were significantly lower in the patient group (P 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P 0.05). Serum superoxide dismutase (SOD) levels in the patient group were significantly low compared to the control group (P 0.001). In the control group, statistically significant positive correlations among HLA-G, MDA (r = 0.580, P = 0.001), and AOPP (r = 0.569, P = 0.01) were observed. In the control group, a significant positive correlation in MDA and AOPP levels (r = 0.482, P = 0.006) was observed. Conclusion: Results of the present study indicated that there was a relationship between the oxidative stress and the deficiency of antioxidant defenses as lipid peroxidation, protein oxidation, and HLA-G expression increased.