Author/Authors :
KAYA, Onur Süleyman Demirel University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , ALP ÇAVUŞ, Sema Dokuz Eylül University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , TURHAN, Özge Akdeniz University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , IŞIKGÖZ TAŞBAKAN, Meltem Ege University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , PULLUKÇU, Hüsnü Ege University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, TURKEY , ERTUĞRUL, Mustafa Bülent Adnan Menderes University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , ŞENOL, Şebnem Celal Bayar University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , ÇETİN, Çiğdem Banu Celal Bayar University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , ÖZHAK BAYSAN, Betil Akdeniz University - Faculty of Medicine - Department of Medical Microbiology, Turkey , SAYIN KUTLU, Selda Pamukkale University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , METİN, Dilek Yeşim Ege University - Faculty of Medicine - Department of Medical Microbiology, Turkey , AVCI, Meltem İzmir Bozyaka Teaching and Research Hospital - Department of Infectious Diseases and Clinical Microbiology, Turkey , MERMUT, Gülşen İzmir Bozyaka Teaching and Research Hospital - Department of Infectious Diseases and Clinical Microbiology, Turkey , AVKAN OĞUZ, Vildan Dokuz Eylül University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey , YAPAR, Nur Dokuz Eylül University - Faculty of Medicine - Department of Infectious Diseases and Clinical Microbiology, Turkey
Abstract :
Aim: Zygomycosis is a severe angioinvasive infection caused by Zygomycetes. We retrospectively investigated 16 cases of zygomycosis. Materials and methods: The data of patients, who had been followed between 2004 and 2010 in 8 tertiary-care teaching hospitals, were reviewed. Demographic characteristics, underlying diseases, and clinical signs and symptoms of the patients, as well as diagnostic methods, data obtained by radiological imaging methods, and the therapies, were recorded. Therapeutic approaches, antifungal agents and duration of use, and the characteristics of the cases were identified. Results: The study included 11 female and 5 male subjects. The most common symptoms and clinical signs were fever (n = 9) and retroorbital pain (n = 7). Rhinocerebral zygomycosis was the most common form. The mean time elapsed for diagnosis was 14.26 ± 13.96 (range: 2–52) days. Antifungal therapy was given to 15 patients (94%). In addition to antifungal therapy, 12 patients underwent surgical intervention 1 to 4 times. The mean duration of receiving antifungal therapy was 61.4 ± 58.02 (range: 1–180) days. The median duration of treatment was 62.5 (range: 42–180) days in survivors. Conclusion: Zygomycosis is an infectious disease with high mortality despite antifungal therapy and surgical interventions.
