Investigation of linezolid resistance in Staphylococcus epidermidis: first reported linezolid resistant coagulase negative staphylococcus in Turkey

Linezolid is a member of oxazolidinons and it inhibits protein synthesis at the initiation step. In this step, formation of 70S complex occurs by association of 50S ribosomal subunit, and 30S initiation complex, which is made of 30S ribosomal subunit, mRNA, and methionine carrying tRNA. Linezolid prevents this formation by binding the 50S subunit (1–3). Although it is a new agent, resistance has been reported from several centers worldwide, but it is still rare. Target modification is the main factor in linezolid resistance.