Author/Authors :
KAYGUSUZ, İkbal Turgut Özal University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , SİMAVLI, Serap Aynur Pamukkale University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , ESER, Ayla Turgut Özal University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , İNEGÖL GÜMÜŞ, İlknur Turgut Özal University - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , YÜKSEL, Selcen Yıldırım Beyazıt University - Faculty of Medicine - Department of Biostatistics, Turkey , İLTEMİR DUVAN, Zehra Candan Gazi Üniversitesi - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey , KAFALI, Hasan Gazi Üniversitesi - Faculty of Medicine - Department of Obstetrics and Gynecology, Turkey
Abstract :
Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.
Keywords :
Mean platelet volume , menopause , cardiovascular risk , hormone replacement therapy , lipid profile
