Author/Authors :
DOĞAN, Orhan Veli Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Cardiovascular Surgery, Turkey , MENTEŞE, Ümit Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Cardiovascular Surgery, Turkey , DOĞAN, Süheyla Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Cardiovascular Surgery, Turkey , USTA, Sefer Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Cardiovascular Surgery, Turkey , TURAN, İbrahim Gümüşhane University - Faculty of Engineering - Department of Bioengineering, Turkey , HALİLOĞLU, Ergün Gümüshane UniversityFaculty of Engineering - Department of Bioengineering, Turkey , KARAHAN, Süleyman Caner Yıldızlı Güven Hospital - Department of Biochemistry, Turkey
Abstract :
To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR). Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated. Results: OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018). Conclusion: Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
