Title of article
Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities
Author/Authors
BAYTAS, Sultan Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , INCELER, Nazan Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY , Fattahpour MAVANEH, Khatereh Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmacology, TURKEY , ULUDAG, Mecit Orhan Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmacology, TURKEY , ABACIOGLU, Nurettin Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmacology, TURKEY , GOKCE, Mehtap Gazi Üniversitesi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, TURKEY
From page
734
To page
748
Abstract
Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.
Keywords
Hybrid , antipyrine , pyridazinone , writhing , carrageenan
Journal title
Turkish Journal of Chemistry
Journal title
Turkish Journal of Chemistry
Record number
2533202
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