Title of article
Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald reaction
Author/Authors
ABAEE, Mohammad Saeed Chemistry and Chemical Engineering Research Center of Iran - Organic Chemistry and Natural Products Department, ايران , CHERAGHI, Somayeh Chemistry and Chemical Engineering Research Center of Iran - Organic Chemistry and Natural Products Department, ايران
From page
650
To page
660
Abstract
In the presence of water and 1,4-diazabicyclo[2.2.2]octane, several aldehydes and cyclic ketones underwent efficient Knoevenagel condensation with malononitrile and ethyl cyanoacetate to produce the respective α . β -unsaturated systems within fairly short time periods. As a result, high yields of conjugated products were easily obtained. Products could be engaged in a Gewald reaction, either stepwise or in situ, to produce efficiently their respective 2-aminothiophenes within 4–7 h.
Keywords
Knoevenagel condensation , Gewald reaction , organocatalysis , aqueous conditions , amine
Journal title
Turkish Journal of Chemistry
Journal title
Turkish Journal of Chemistry
Record number
2533364
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