Title of article :
Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities
Author/Authors :
HOSSAIN, Mohammad Shakhawoat Middle East Technical University - Department of Chemistry, Turkey , POLAT ÇAKIR, Sıdıka Çanakkale Onsekiz Mart University - Engineering and Architecture Faculty - Department of Chemical Engineering, Turkey , KARADUMAN, Ayşe Betül Eskişehir Osmangazi University - Graduate School of Natural and Applied Sciences, Turkey , YAMAÇ, Mustafa Eskişehir Osmangazi University - Faculty of Science and Arts - Department of Biology, Turkey , DEMİR, Ayhan Sıtkı Middle East Technical University - Department of Chemistry, Turkey
Abstract :
A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
Keywords :
Acyl phosphonates , alkynyl organoaluminum , propargylic alcohols , tris , (phenylethynyl)aluminum , tris , (propynyl)aluminum , antimicrobial activity
Journal title :
Turkish Journal of Chemistry
Journal title :
Turkish Journal of Chemistry
