Title of article :
Platelet Microparticle Controversial Role in Cancer
Author/Authors :
Nazari, Mahnaz Hematology and Oncology Research Center - Tabriz University of Medical Sciences , Javandoost, Ehsan Student Research Committee - Tabriz University of Medical Sciences , Talebi, Mehdi Hematology and Oncology Research Center - Tabriz University of Medical Sciences , Movassaghpour, Aliakbar Hematology and Oncology Research Center - Tabriz University of Medical Sciences , Soleimani, Masoud Department of Hematology - Tarbiat Modares University
Abstract :
Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles
released by platelets upon activation that are responsible for the majority of microvesicles
found in plasma. PMPs’ physiological properties and functions have long been investigated
by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the
potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence
conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many
of these functions could be deemed as a cornerstone for future considerations of PMPs usage
in cancer targeted therapy. This review discusses what is currently known about PMPs and
provides insights for new and possible research directions for further grasping the intricate
interplay between PMPs and cancer.
Keywords :
PMP , Platelet , Microparticle , Cancer
Journal title :
Advanced Pharmaceutical Bulletin
