Title of article
Loading Drug on Nanostructured Ti6Al4V-HA for Implant Applications
Author/Authors
Abbaspoura, S. School of Science and Engineering - Sharif University of Technology - International Campus, Kish Island , Sadrnezhaad, S.K Department of Materials Science and Engineering - Sharif University of Technology, Tehran
Pages
7
From page
1159
To page
1165
Abstract
Arrayed Ti6Al4V nanotubes (TNT) coated with hydroxyapatite (HA) were synthesized via electrochemical anodization method. Paracetamol was loaded onto TNT-HA electrode. Effects of anodization, nanotube formation and hydroxyapatite deposition on sorption and release of the drug were investigated. Saturation time of paracetamol on the anodized samples was 30% shorter than the hydroxyapatite-coated samples. Release behavior of the loaded drug was studied by (a) plunging the probe into phosphate buffered saline (PBS), (b) sampling the drug-loaded PBS at different times and (c) analyzing the solution via ultraviolet-visible (UV-vis) spectroscopy. Results showed that HA electrodes hold higher amounts of paracetamol than the anodized samples at longer times. Scanning electron microscopy (SEM), MTT assay, and nanoindentation tests were used to characterize the produced electrodes.
Keywords
Titanium nanotubes , Drug capacity , Drug release , Hydroxyapatite , Paracetamol
Journal title
International Journal of Engineering
Serial Year
2018
Record number
2535192
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