Author/Authors :
N’guessan, JD Laboratoire de Pharmcodynamie Biochimique, Ivory Coast , Guessennd, N Institut Pasteur de Côte d’Ivoire - Département de Bactériologie Virologie, Ivory Coast , Coulibaly, A Laboratoire de Pharmcodynamie Biochimique, Ivory Coast , Dosso, M Institut Pasteur de Côte d’Ivoire - Département de Bactériologie Virologie, Ivory Coast , Djaman, AJ Institut Pasteur de Côte d’Ivoire - Laboratoire de Biochimie, Ivory Coast , Guede-Guina, F Laboratoire de Pharmcodynamie Biochimique, Ivory Coast , Dinzedi, MR Laboratoire de Pharmcodynamie Biochimique, Ivory Coast , Dinzedi, MR Institut Pasteur de Côte d’Ivoire - Département de Bactériologie Virologie, Ivory Coast
Abstract :
Purpose: The aim of this study was to evaluate the antimicrobial activity of Thonningia sanguinea against two sensitive and two multi-drug resistant (ESBL) Enterobacteria strains namely Escherichia coli and Klebsiella pneumoniae. Method: The confirmation of the ESBL producing strains was done by the double-disc synergy tests and the broth dilution method was used for the determination of theantimicrobial parameters (MIC and MBC) on these sensitive and ESBL producing strains. Results: The two sensitive strains had the same MIC and MBC values respectively 3.125 mg /ml and 12.50 mg/ml. The ESBL producing strains also had the same MIC of 6.25 mg /ml and MBC values of 25 mg/ml. The extract was bactericidal for all tested strains. Conclusion: The results suggest that the flowers of T. sanguinea can be used in association with antibiotics for alternative therapy of diseases caused by ESBL producing E .coli, K. pneumoniae.
Keywords :
antimicrobial activity, Thonningia sanguinea, ESBL producing strains , E .coli.
