Comparison of Weibull and Probit Analysis in Toxicity Testing of Hunteria umbellata K Schum (Apocynaceae) Extract in Mice

Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statisticalanalysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice. Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports. Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.