Title of article
Extensive myelofibrosis responsive to treatment for acuteerythroblastic leukaemia
Author/Authors
S-Abdul-Wahid, Fadilah Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Medicine, Malaysia , S-Abdul-Wahid, Fadilah Universiti Kebangsaan Malaysia - Clinical Haematology and Stem Cell Transplantation Services, Malaysia , Raja-Sabudin, Raja-Zahratul-Azma Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Pathology, Malaysia , Leong, Chooi-Fun Universiti Kebangsaan Malaysia - Faculty of Medicine - Departments of Pathology, Malaysia , Leong, Chooi-Fun Universiti Kebangsaan Malaysia - Clinical Haematology and Stem Cell Transplantation Services, Malaysia
From page
55
To page
58
Abstract
Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.
Keywords
myelofibrosis , acute erythroblastic leukaemia (AML , M6) , acute megakaryoblastic leukaemia (AML , M7) , primary (idiopathic) myelofibrosis , marrow fibrosis
Journal title
The Malaysian Journal of Pathology
Journal title
The Malaysian Journal of Pathology
Record number
2537540
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