Title of article :
Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma
Author/Authors :
HOE, Susan Ling Ling Institute for Medical Research - Cancer Research Centre - Molecular Pathology Unit , LEE, Ee Soo Institute for Medical Research - Cancer Research Centre - Molecular Pathology Unit, Malaysia , KHOO, Alan Soo Beng university of malaya - Faculty of Medicine - Pathology Department, Malaysia , PEH, Suat-Cheng Institute for Medical Research - Cancer Research Centre - Molecular Pathology Unit, Malaysia
Abstract :
The retinoblastoma-related gene Rb2/p130 has been reported to be mutated in several malignancies such as lung cancer and Burkitt’s lymphoma. Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia especially amongst the ethnic Chinese. We screened for Rb2/p130 gene (exons 19 to 21) mutations in 53 archival NPC samples via PCR-SSCP-direct sequencing approach. Only one sample had a base change which involved a serine to glycine substitution at codon 995 (S995G). We conclude that Rb2/p130 genetic alterations are infrequent in NPC and may not be essential for the pathogenesis of the disease.
Keywords :
Rb2 , p130 gene , nasopharyngeal carcinoma , PCR , SSCP
Journal title :
The Malaysian Journal of Pathology
Journal title :
The Malaysian Journal of Pathology
