Author/Authors :
SAYED, MAGDA Cairo University - National Cancer Institute - Department of Biochemistry, Egypt , ABD EL KADER, MONIRA A. Al-Azher University - Faculty of Medicine, Egypt , HUSSEIN, ADEL Al-Azher University - National Research Center and Internal Medicine - Department of Biochemistry, Egypt
Abstract :
Background: The aim of the present study was to evaluate levels of von Willebrand Factor and E- selectin in essentional hypertensive patients, before and after successful hypertension therapy, although correlated them with other traditional atherosclerosis risk factors (lipid parameters, blood pressure values and BMI) as well as an attempt to answer the question wether Von willebramand factor and E-selectin can be useful in predicting atherosclerosis in essential hypertensive patients. Patients and Methods: The study was conducted on 30 essential hypertensive patients before (GI) and after (Gil) hypertensive therapy, in addition to 15 healthy age and sex matched normotensive adults as a control group. All members of the study were subjected to: Throughout clinical examination, Liver function tests, Kidney function tests, Determination of body mass index, Blood pressure measurements, in addition to evaluation of levels of fasting post prandial blood sugar, total cholesterol, HDL-chole, LDL-chole, triglycerides, E- selectin in serum and plasma vonWillebrand Factor. Results: The results of the study showed a significant elevation in serum cholesterol, LDL- cholesterol, HDL- cholesterol, triglycerides and plasma vonWillebrand Factor in GI (essential hypertensive patients before hypertension therapy) and Gil (essential hypertensive patients after hypertension therapy) as compared to control group. There was a significant reduction in the elevated parameters after 6 months of antihypertension therapy. The plasma vWF level showed a positive significant correlation with body mass index (BMI) in all studied groups (GI, Gil C). The levels of E-selectin showed a non significant in GI Gil as compared to control group. Conclusion: The plasma vWF, serum T.cholesterol, LDL- chole. and triglycerides in essential hypertensive patients were higher than those in normotensive control. Also, plasma vonWillebrand Factor had a positive significant correlation with body mass index (BMI) in all studied groups (an important atherosclerotic risk factor), So, vWFcould play some role in pathogenesis of endothelial damage in essential hypertensive patients, it can be used as a complementry test with T.cholesterol, LDL-cholesterol and triglycerides to detecte essential hypertensive patients at risk of atherosclerosis.
Keywords :
Essential hypertension , E , selectin , vONWille , brand Factor (vWF) , Endothelial damage.
