Using of Angelica Officinalis Roots Powder as a Chelating Agent of Lead in Rats

Lead poisoning still a dominant problem in all countries world wide. Treatment of lead poisoning is called chelation therapy. The aim of this work was to verify the chelation potency of angelica officinalis herb water extraction as it mentioned before in the Traditional Arabic Method. Results obtained by application of this extraction compared with those obtained from application of the most common chelator in the world (DMSA). Results showed a strong chelation potency of the extraction against lead in blood, bone, liver and brain. Natural chelator was better that derived chemically hence no free radicals formed through chelation process, that verified by measuring the SOD and glutathione peroxidase activity. Groups received treatment without continuous exposure to lead gave better results than those received the treatment with continuous exposure to lead, i.e. it is very essential to avoid the toxicity test before starting the treatment courses.