Concurrent Cisplatin and Concomitant Boost Radiation Therapy in the Treatment of Locally Advanced Squamous Cell Cancer of the Head and Neck

Purpose: To determine the efficacy and toxicity of a treatment regimen that combined concomitant boost accelerated radiation therapy with cisplatin, in patients with locally advanced squamous cell cancer of the head and neck.Patients and Methods: Thirty-two patients with stage III to IV squamous cell cancer of the head and neck were enrolled in this study. They were treated with 70Gy radiotherapy including concomitant boost (CB) regimen (1.8Gy/d, weeks1through 6) then (l.6Gy second daily fraction, during weeks 5 and 6) and two cycles of concurrent cisplatin 100mg/m2 on days I and 22. Tumor and clinical status were assessed and also regimen s toxicities were graded.