Title of article :
Retinal Histopathological Changes Following Intravitreal Injection of Different Doses of Bevacizumab: An Electron Microscopic Study
Author/Authors :
HASSAN, MANSOUR H. Cairo University, Beni Soueif Branch - Faculty of Medicine - Department of Ophthalmology, Egypt , EL-AGHA, MOHAMAD-SAMEH H. Cairo University, Beni Soueif Branch - Faculty of Medicine - Department of Ophthalmology, Egypt , SAIF, MOHAMAD YASSER S. Cairo University, Beni Soueif Branch - Faculty of Medicine - Department of Ophthalmology, Egypt , ZAKI, AMANULLAH M. Ain Shams University - Faculty of Science - Central Laboratory, Egypt
Abstract :
Purpose: To determine the retinal toxicity of intravitreal bevacizumab in rabbits by electron microscopy. Methods: Six albino rabbits received one injection of intravitreal bevacizumab in one eye, and no injection (control) in the fellow eye. Two rabbits received 1.25mg in 0.05ml, two received 2.5mg in 0.1 ml, and two received 5mg in 0.2ml. For each dose of bevacizumab, one rabbit was sacrificed one day after injection, and the other one week later. The retina was then examined by transmission electron microscopy.
Keywords :
Bevacizumab , Intravitreal , Retinal toxicity.
Journal title :
The Medical Journal of Cairo University
Journal title :
The Medical Journal of Cairo University
