Author/Authors :
SALEEM, TAHIA H. Assiut University - Faculty of Medicine - Department of Biochemistry, Egypt , NAFADEE, HOWIDA A. Assuit University - Faculty of Medicine - Department of Internal Medicine, Egypt , OREBI, ANWAR M. Minia University - Faculty of Medicine - Department of Internal Medicine, Egypt , TELEB, SALWA G. Minia University - Faculty of Medicine - Department of Pathology, Egypt , HUSSAIN, ABDEL-FATAH MOHAMAD Minia University - Faculty of Medicine - Department of Internal Medicine, Egypt
Abstract :
Type 2 diabetes mellitus is associated with metabolic disorders characterized by excessive oxidative stress, deficiency of antioxidants and dyslipidemia resulting in endothelial injury. Microalbuminuria is a powerful prognostic indicator of morbidity and mortality with type 2 diabetes mellitus. The present study included 130 individuals divided into 2 groups. Group I included 34 apparently healthy individuals served as control group with the mean age 27.2±7.4 years (range 23- 36). Group II included 96 patients with type 2 diabetes mellitus their mean age was 52.7±6.7 years (range; 30-65 years). Clinical and laboratory data of both groups were reported. Group II was subdivided into 2 subgroups according to the absence and presence of microalbuminuria. There was significant increase in the age, weight, blood glucose, lipid profile, vWF, urinary albumin, total protein, HbA1C, serum creatinine, blood urea and GFR in patients with type-2 diabetes mellitus (group II) versus group I. Also, there was a high prevalence of smoking (76%) and hypertension (62.5%) in group II. In-group II, microalbuminuria was found in 92.7%, high vWF was found in 17.7% patients, and low GFR was found in 51 % patients. In-group II, vWF was strongly correlated with low GFR and microalbuminuria. As regards the level of vWF, there was a high significant difference in age, duration of type-2 diabetes mellitus, HbA1C%, serum creatinine and GFR in patients with high vWF than in patients with normal vWF. When patients with abnormal GFR were compared to patients with normal GFR, there was a high significant difference in age, duration of diabetes, weight, vWF, urinary albumin, HbA1C, serum creatinine and GFR. In-patients with low GFR, there was a high prevalence of high vWF and microalbuminuria. In type-2 diabetes mellitus patients with microalbuminuria, there was 45% patients in stage I of renal affection, 39.7% patients in stage II of renal affection and 15.7% patients in stage III of renal affection. There was significant difference in stages of renal affection, when patients with and without microalbuminuria were compared together. It can be concluded that the risk of renal damage among microalbuminuric type-2 diabetic patients is much higher when high vWF concentration is present.
