The Aetiology of Genetic, Acquired and Sporadic Prion Diseases

Based on the protein X or the chaperone protein hypothesis which enables the reaction of conversion from PrPc to PrPSc and the gene interaction of this protein with prion protein gene (PRNP gene) we do propose the genotypes involved and give possible explanations of genetic, sporadic and acquired forms of prion diseases. In this context, the genetic forms of prion diseases like fCJD, fGSS and FFi have A-B genotypes. In these genotypes, PRNP gene and Xchap have been subject to a dominant mutation. In the sporadic forms of prion diseases like sCJD and sFI, the Xchap gene has been subject to dominant mutation but in the acquired forms of prion diseases (kuru, iCJD and VCJD) the PRNP gene has been subject to a dominant mutation.