Author/Authors :
ABDEL HADY, AMR Cairo University - Faculty of Medicine - Department of Internal Medicine, Egypt , MAHMOUD, ALAA Cairo University - Faculty of Medicine - Department of Internal Medicine, Egypt , ADLY, MANAL Cairo University - Faculty of Medicine - Department of Internal Medicine, Egypt , FATHY, MARYAN Cairo University - Faculty of Medicine - Department of Chemical Pathology, Egypt , MOHAMED, ELHAM Cairo University - Faculty of Medicine - Department of Internal Medicine, Egypt
Abstract :
Background: In type 2 diabetes, endothelial dysfunction is detectable very early in the course of the disease and vWF is a well-known marker of endothelial dysfunction and can be detected early and used as a marker of endothelial dysfunction in type 2 diabetes.Objective: Measure plasma levels of vWF activity in patients with type 2 DM and to evaluate its utility in the early detection of endothelial dysfunction in comparison to other known factor of endothelial dysfunction as FMD.Study Design: This study was conducted on 50 patients with type 2 diabetes mellitus chosen from diabetic outpatient clinic at Kasr Al-Ainy University Hospital in the period from 2009 to 2011 there was classified into two groups: Group I which included 25 type 2 diabetes patients with normal UAE and group II included 25 patients with type 2 diabetes with microalbuminuria and 20 healthy volunteers serve as control group.Results: In the present study plasma levels of vWF are significantly higher in patients with type 2 diabetes with normal UAER (group I) and in patients with microalbuminuria (group II) compared to controls also FMD of brachial arterywas significantly diminished in diabetic patients with microalbuminuria (group II) than diabetic patients with no microalbuminuria (group I) with no significant difference between diabetic patients with no microalbuminuria and control group.Conclusion: Plasma vWF activity can be used as an early marker of endothelial dysfunction in type 2 diabetes.
