Is Use of Misoprostol Considered Safe for Second Trimester Pregnancy Termination with a Prior CS Scar?

Objective: To evaluate the safety of misoprostol for pregnancy termination in women with prior scar of Cesearean section.Design: Prospective controlled trial.Participants and Methods: 210 women classified into 2 groups: Group I (cases) included 80 women with uterine scar and group II (control) included 130 women without uterine scar. Misoprostol (50μg) (2 vagiprost 25μg) was administered vaginally every 4 hours for a maximum of 72 hours. Before the next dose, the patient was examined and if the patient was having adequate contractions (3 in 10min) or cervix was dilated 4cm d lated, the next dose was d ferred. S de effects were recorded. Induction to abortion interval and doses needed were reported.Results: Only one case had rupture uterus in Group I while no cases of rupture uterus were encountered in Group II. There was no significant difference between both groups regarding other side effects. There was a fair, yet statistically significant positive correlation between both parameters (r=0.112, p=0.03), denoting need for more doses of misoprostol with increasing gestational age.Conclusion: It seems that the use of misoprostol for second trimester pregnancy termination is safe and applicable.