Role of Septilin in Treatment of Radiation Induced Testicular Injury

The protective effects of Septilin (herbal extract) against radiation-induced damage in testis of male rats have been studied Animals were divided into four main groups: 1- Control group, 2- Septilin group (100mg/kg body weight/day). 3- Irradiated group (4Gy gamma-radiation), 4-Protected group in which animals (Male rats) were given Septilin orally (100mg/kg body weight/day) for two weeks before radiation exposure (4Gy gammaradiation), then rats were regiven Septilin treatment again following irradiation and were autopsied at the third and seventh days after treatment to evaluate the effectiveness of the treatment before and following radiation in terms of histological alterations in rats testis. The irradiated group showed marked testicular degeneration, interstitial edema and degeneration of spermatogonial cells in seminiferous tubules. The tubules were damaged and greatly depleted of germ cells. However, animals treated with Septilin pre and post-irradiation showed almost normal testicular morphology with regular arrangement of germ cells. Slight testicular degenetation was still observed. Also, presence of some spermatozoa with in the lumen of some tubules was noticed. Conclusion: Thus, this study concluded that gamma-irradiation exerts damaging effects on rat testes. Pre (protective) and post-treatment with Septilin inhibited most of these toxic effects. The protection afforded with Septilin in the present study proved to be beneficial for the clinical use of such herbal extract as a radio protector.