Association of Obesity and Diabetes with Serum Prostate-Specific Antigen Levels in Egyptian Males

Background: An inverse association between diabetes and prostate-specific antigen (PSA) levels was observed, and several studies reported lower PSA levels in groups with higher body mass index. Aim of Work: This study was designed to evaluate the relationships between serum PSA level, obesity, and diabetes in Egyptian males. Subjects and Methods: The study included 100 previously diagnosed type 2 diabetic males (50 obese, 50 non obese) attending the outpatient clinics of NIDE and 50 normal controls. Blood pressure, waist circumference, BMI, FBS, HBA1c, lipid profile, fasting insulin level, urea, creatinine, uric acid. Microalbuminurea and PSA were measured. Fundus examination, chest X-ray and ECG were performed for all subjects and echocardiography was done when indicated. Results: PSA was significantly lower in type 2 diabetic patients (m=0.99±0.26ng/mL) compared with the control subjects (1.16±0.27ng/mL) (p 0.001). There was a highly significant statistical difference among the three studied groups being lower in obese type 2 diabetic patients (m=0.88±0.18), than non obese type 2 diabetic patients (m=1.01±0.22) than normal controls (m=1.16±0.27) (p-value 0.05). There was a highly significant statistical positive correlation between prostate-Specific Antigen and age (r=+0.49; p 0.01). There was also a statistically significant negative correlations between Prostate-Specific Antigen and both body mass index (r=–0.43; p 0.05) and HBA1c (r=–0.41; p 0.05). Conclusion: Our findings suggest that PSA was significantly lower in type 2 diabetic patients compared with normal controls being higher in older patients and lower in patients with higher body mass index and elevated HBA1c.