Title of article :
Clinicopathological Characteristics of Triple-Negative Breast Cancer
Author/Authors :
EL-HENNAWY, AHMED M.Y. Cairo University - Faculty of Medicine - Department of Pathology, Egypt , GABAL, SAMIA M. Cairo University - Faculty of Medicine - Department of Pathology, Egypt , SALEM, MOSTAFA S. Cairo University - Faculty of Medicine - Department of Pathology, Egypt , ALI, MOHAMMED M.A. Fayoum University - Faculty of Medicine - Department of Pathology, Egypt , AMIN, HEBAT ALLAH A. Ministry of Justice - Egyptian Forensic Medicine Authority, Egypt
Abstract :
Background: Triple Negative Breast Carcinomas (TNBCs) are a group of primary breast tumors with aggressive clinical behavior that have no targeted therapy at present. Comparative studies for subtypes of triple negative group of invasive breast carcinoma are needed to detect any specific morphologic features of this group. Results: The study included 40 cases of triple negative breast cancer. All cases were subjected to pathological study regarding gross and microscopic features. Results showed that 25 cases (62.5%) were invasive ductal carcinoma (NOS), 10 cases (25%) were medullary and 5 cases (12.5%) were metaplastic. The majority of cases were found to be T2 (17 cases representing 42.5%). 11 cases (27.5%) showed negative axillary node deposits, 11 cases (27.5%), showed deposits in 1-3 lymph nodes; 14 cases (35.0%) showed 4-9 nodal deposits and only 4 cases (10.0%) showed more than 9 nodes (10%). According to Modified Bloom Richardson grading system, 24 cases (60%) were GIII.
Keywords :
Basal phenotype breast cancer , EGFR , Targeted therapy , TNBC , Triple negative breast cancer
Journal title :
The Medical Journal of Cairo University
Journal title :
The Medical Journal of Cairo University
