Author/Authors :
ZIDAN, MAGDA Benha University - Faculty of Medicine - Department of Clinical Chemical Pathology and Pediatrics, Egypt , KAMAL, HOWYDA M. Benha University - Faculty of Medicine - Department of Clinical Chemical Pathology and Pediatrics, Egypt , EL-BEHISY, MONA M. Benha University - Faculty of Medicine - Department of Clinical Chemical Pathology and Pediatrics, Egypt , ABDEL HAIE, OMIMA M. Benha University - Faculty of Medicine - Department of Clinical Chemical Pathology and Pediatrics, Egypt , NASSER, MAI Benha University - Faculty of Medicine, Egypt
Abstract :
Objective: To asses the role of Triggering receptor expressed on myeloid cells-1 (TREM-1) as a potential early diagnostic marker of neonatal sepsis.Methods: Studied neonates were evaluated for sepsis using clinical and laboratory measures. sTREM-1 was measured in the serum by Enzyme Linked Immunosorbant Assay (ELISA) on admittion 48 hour after antibiotic therapy. Another 10 blood samples from healthy neonates age sex matched to cases were analysed for sTREM-1 as a control group.Results: Baseline sTREM-1 levels were significantly elevated in septic neonates (10 11. 1±594.93pg/mL) compared to controls (136.6±41.3pg/mL) it was significantly decreased 48h after antibiotic therapy compared to baseline sTREM-1 level. sTREM-1 was increased in culture positive culture negative cases with no significant difference between them. Septic preterm neonates had significantly higher sTREM-1 compared to full term neonates. sTREM-1 was significantly higher in neonates with early onset sepsis than late onset sepsis neonates. The cutoff value of 250pg/mL could be diagnostic for neonatal sepsis (NS) with 97.1% sensitivity and 90% specificity (AUC, 0.97).Conclusion: High serum sTREM-1 could be considered an early diagnostic marker of neonatal sepsis.
