Study of Galactorrhea in Infertile Women and its Correlation with Hypothyroidism in Egyptian Women

Background: Female infertility refers to infertility in female humans. It affects an estimated 48 million women with the highest prevalence of infertility affecting people in South Asia Sub-Saharan Africa, North Africa/Middle East and Central/Eastern Europe and Central Asia 19% of the women had primary infertility and the others secondary infertility. The menstrual pattern was abnormal in 37.8% of infertile women with galactorrhoea.Objectives: To estimate the three hormones Prolactin, Thyroid Stimulated Hormone (TSH) and Free Thyroxine (F-T4) in infertile females with galactorrhea and its correlation with hypothyroidism.Methods: 72 women participated in this study in two groups:- Group I that composed of 36 1ry infertility women complained with galactorrhea.- Group II composed from 36 healthy women as a control group. Their ages ranges from 21 to 30 years. Estimation of three hormones PRL-TSH-FT4 that were analysed by chemiluminescence immunoassay (cobas) in two groups.Results: Significant higher value of (PRL) and (TSH) (p 0.001) were observed in the patient Group (I) when compared with control Group II. While significant lower values (p 0.001) in F-T4 were observed in patients of Group I. When compared with control Group II.Conclusions: There is a high incidence of hyperprolactinaemia in 1ry infertile women mainly with galactorrhea and there is a good positive correlation between hypothyroidism and hyperprolactinemia.