Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy

Background: Post-operative nausea and vomiting (PONV) is one of the common problemsafter laparoscopic cholecystectomy.Objectives: The current study aimed to compare Dexamethasone effect with that ofGranisetron in prevention of PONV.Patients and Methods: In the current study 104 patients aged 20-60 with ASA class I orII who were candidates for laparoscopic cholecystectomy were included in the study. Patientswere randomly divided into two groups of A and B. 15 minutes before anesthesiainduction, in group a patient’s 3 mg Granisetron and in group B patients 8 mg Dexamethasonewas intravenously injected. Then both groups underwent general anesthesiawith similar medications. After operation the prevalence of nausea and vomiting was assessedat three time intervals (0-6 hours, 6-12 hours and 12-24 hours after consciousness).SPSS software version 16 was employed to analyze data. T test, chi-square test and Fischerexact test were performed level of significance was P 0.05.Results: There was no significant difference between age, gender proportion, weight,height, and body mass index (BMI) of patients in the two groups. In Dexamethasonegroup, seven patients experienced nausea and three patients had vomiting, and inGranisetron group, five patients experienced nausea and three patients had vomitingafter consciousness. Statistical analysis indicated no significant difference between thetwo groups in this regard.Conclusions: Intravenous injection of 8 mg Dexamethasone or 3 mg Granisetron beforeanesthesia induction had similar effects in prophylaxis of nausea and vomiting afterlaparoscopic cholecystectomy.