Propofol Alleviates Intractable Migraine Headache: A Case Report

Several medications have been proposed as the first line drugs in the treatment of migraineattack. However, the low efficacy, potential complications of medications and theintolerance of some patients for oral route due to nausea and vomiting establish a difficultsituation in some migraine patients. This report describes a dramatic pain reliefwith 60 mg of intravenous propofol in a patient with migraine attack refractory to treatmentwith metoclopramide, promethazine, dexamethasone and meperidine. Pain reliefin this patient besides earlier case reports suggests that subanesthetic doses of propofolmay be an alternative to other treatment modalities for acute migraine.