Author/Authors :
SHAARAWY, EMAN Cairo University - National Research Center - Department of Dermatology, Egypt , ABD EL-HAY, RANIA Cairo University - Faculty of Medicine - Department of Dermatology, Egypt , SAMIR, NESRINE Cairo University - National Research Center - Department of Dermatology, Egypt , KHORSHIED, MERVAT Cairo University - Faculty of Medicine, National Research Center - Department of Clinical and Chemical Pathology, Egypt , GOUDA, HEBA Cairo University - Faculty of Medicine, National Research Center - Department of Clinical Pathology, Egypt , HELWA, IMAN Cairo University - National Research Center - Department of Dermatology, Egypt , EL-ZAWAHRY, YASMIN B. Cairo University - National Research Center - Department of Dermatology, Egypt
Abstract :
Background: Alopecia Areata (AA) is an autoimmune disease characterized by T-cell infiltrates and cytokine production around anagen hair follicles. The aetiology of AA includes genetic susceptibility, environmental and immunological factors.Objective: To study the possible association of IL-1β-C-511T and C+3953T Single Nucleotide Polymorphism (SNP) with AA.Methods: This case-control study was conducted on 100 AA patients and 100 controls. Three ml venous blood was withdrawn from every participant for genotyping of IL-1B-511 C/T, and IL-1B +3954 C/T SNPs using PCR-RFLP technique.Results: The studied genotype distribution and allele frequencies showed no significant difference between AA patients and healthy controls, apart from IL-1β+3953 C allele that was found more frequently than T allele among cases and controls.Conclusion: IL-1β C-511T and C+3953T SNPs have no etiological role in our studied Egyptian AA patients.
Keywords :
Alopecia areata , Genetic predisposition , Interleukin , 1
