Effect of Resistive Exercise Training on Osteocalcin Level in Type II Diabetic Patients

Background: Exercises are often recommended for patients with Type 2 Diabetes Mellitus (T2DM) to improve physical condition and glycemic control. Exercise causes mechanical loading on bone which plays a major role in improving glycemic control through secretion of osteocalcin that improves insulin sensitivity and insulin secretion. Aim of this Study: To determine the impact of resistive training on osteocalcin and glycated hemoglobin (HbA1c) in T2DM on a short-term basis (after 12 weeks of training). Patients and Methods: Forty type two diabetic women were randomly assigned into two equal Groups (A and B). Group (A): Resistive (circuit weight training) group who participated in resistive training program three times per week for 12 weeks besides their routine medications. Group (B): Control group received their medications only. Osteocalcin, HBA1c and BMI were measured before and after completion of the study. Results: Patients in Groups A and B showed significant increase of osteocalcin level and significant decrease of HBA1C and BMI. Statistical analysis showed significant increase in osteocalcin level in both groups with significant difference between them in favor of Group A. Conclusion: Regular participation in resistive exercise training is effective in increasing osteocalcin level and improving HBA1C in type two diabetic patients.