Relationship between Serum Heat-Stable Alkaline Phosphatase Activity and Blood Pressure in Patients with Pre-Eclampsia and Eclampsia

Background: The objective of this study was to explore the relationship, if any, between the serum heat-stable alkaline phosphatase (HS-ALP) activity and the blood pressure (BP) of patients with pre-eclampsia and eclampsia. Method: The activity of HS-ALP was measured using the 4 – nitrophenyl phosphate (4 – NPP) method after incubation at a high temperature of 65 °C for exactly 30 minutes in one hundred normal pregnant women and in another one hundred with pre-eclampsia/eclampsia. The normal pregnant women were used as controls. The blood pressure (BP), systolic as well as diastolic was measured in each of the studied patient using desktop mercury sphygmomanometer. Results: In the patients with pre-eclampsia/eclampsia, it was found that the higher the systolic and diastolic BP, the higher is the activity of the HS-ALP. Conclusion: It can be concluded that the HS-ALP activity in patients with pre-eclampsia/eclampsia is positively related to the severity of the hypertension and therefore this could help in detecting early complication.