Biological Impacts of MicroRNAs in Covid-19: Implications for Anti-Viral miRNA-Based Therapies

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)is anovel severpathogenic coronavirus(CoVs) causing coronavirus disease 2019 (COVID-19), which has become an international concern due to the outbreak and crucial health burden worldwide. SARS-CoV-2 belongs to Coronaviridae family, which are positive single-stranded RNA and contains the largest RNA genome in viruses (1). Interestingly, miRNAs are small non-coding regulator RNAs that involved in various biologic and pathologic processes such as inflammatory responses as well as viral infection. It has been shown that miR-9, miR-98, miR-223, and miR- 214 expression in CoVs-infected host cells could be changed and subsequently leads to modification in cytokines production (2).