Author/Authors :
Mahyar, Abolfazl Department of Pediatrics - Qazvin University of Medical Sciences, Iran , Ayazi, Parviz Department of Pediatrics - Qazvin University of Medical Sciences , Hanafizadeh, Behnor Department of Pediatrics - Qazvin University of Medical Sciences , Arad, Banafsheh Department of Pediatrics - Qazvin University of Medical Sciences , Dalirani, Reza Department of Nephrology - Shahid Beheshti University of Medical Sciences , Sahmani, Ahmad Ali Department of Pediatrics - Qazvin University of Medical Sciences
Abstract :
Background: Leptin is a hormone that plays an important role in human health against infections. Some studies have reported that leptin acts as a reactant phase marker in some infectious diseases. The role of leptin in febrile urinary tract infection (UTI) has not been adequately evaluated.
Objectives: This study was conducted to determine the role of serum leptin in febrile UTI in children.
Methods: Thirty-nine febrile UTI patients were compared with 40 healthy children for the serum leptin level. Serum leptin was measured by the enzyme-linked immunosorbent assay method. The results were compared between the groups.
Results: Median (IQR) of serum leptin in the case and control groups was 2 ng/mL and 0.6 ng/mL, respectively. A significant di er-ence was observed between the groups in the serum leptin level (P = 0.001). No significant di erence was observed between cystitis and acute pyelonephritis patients in the serum leptin level. The correlation analysis showed no significant association between the serum leptin level and acute-phase reactant markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (r =-0.13 and P = 0.41; r = -0.15 and P = 0.36, respectively).-0.13 and P = 0.41; r = -0.15 and P = 0.36, respectively).
