Title of article :
An Experimental and Theoretical Study on Bicyclo-3,4-Dihydropyrimidinone Derivative: Synthesis and DFT Calculation
Author/Authors :
Seif ، Noshin Department of Chemistry - Islamic Azad University, Khuzestan Science and Research Branch , Farhadi ، Asadollah Department of Chemistry - Islamic Azad University, Ahvaz Branch , Badri ، Rashid Department of Chemistry - Islamic Azad University, Ahvaz Branch , Kiasat ، Ali Reza Department of Chemistry - Islamic Azad University, Ahvaz Branch
Abstract :
We report here an efficient and green method for fused Biginelli condensation reaction of aldehydes, cyclopentanone, and urea catalyzed by nano ZrO2-SO3H under solvent-free conditions. The prospect of the reusability of this catalyst has also been demonstrated without compromising on the yield of the product. On the whole, the protocol presented here is an excellent alternative to many of the previously reported procedures. So, Optimized molecular structures have been investigated by DFT/B3LYP method with 6-31G (d,p) basis set. Stability of some 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-4-phenyl-2H-cyclopenta[d]pyrimidin-2-one (2 a-j) derivatives and intramolecular interactions bond has been analyzed by using natural bond orbital (NBO) analysis.
Keywords :
Fused Biginelli condensation reaction , 4 , aryl , 7 , benzylidene , 1,3,4,5,6,7 , hexahydro , 4 , phenyl , 2H , cyclopenta[d]pyrimidin , 2 , one , DFT , B3LYP , NBO
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
