Treatments for fibrosis of the corpora cavernosa

Introduction: Corporal fibrosis usually occurs after explantation of an infected penile prosthesis, severe penile trauma, refractory low-flow priapism, Peyronie’s disease, or the chronic intracavernous injection of vasoactive drugs. Methods: We analysed current treatmentss for penile fibrosis. We searched Pub-Med using the keywords ’penile corporal fibrosis’, ’treatment’ and ’penile fibrosis’,resulting in 63 matches, of which 19 articles met the inclusion criteria. Results and conclusions: This review covers conservative medical therapy for corporal fibrosis and surgical therapeutic methods. The roles of phosphodiesterase- 5 inhibitors and pentoxifylline are analysed. Surgical therapy includes implantation of a penile prosthesis and corporal reconstruction, and these are reviewed. Corporal fibrosis is a major problem for patients, and is associated with severe erectile dysfunction.Conservative treatment options can be applicable in the early phase, but simultaneous corporal reconstruction procedures with concomitant implantation of a penile prosthesis should be attempted in severe cases of corporal fibrosis.