Author/Authors :
Hosseini-Moghaddam, Mohammadmehdi Western University - London Health Sciences Centre, Canada , Hosseini-Moghaddam, Mohammadmehdi shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Keyvani, Hossein iran university of medical sciences - Department of Virology, ايران , Soleimanirahbar, Ata shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Karimi, Gharib Iranian Blood Transfusion Organization, ايران , Daneshvar, Simin shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Basiri, Abbas shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Razzaghi, Zahra shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Nafar, Mohsen shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Pour-Reza-Gholi, Fatemeh shahid beheshti university of medical sciences - Urology and Nephrology Research Center (UNRC), تهران, ايران , Farhangi, Soudabeh Shahid Labbafinejad Medical Center, ايران
Abstract :
Background: Different reports from Middle East countries demonstrated Kaposi’s sarcoma (KS) in transplant population. This vascular malignancy occurs mostly among immunocompromised individuals. Human herpesvirus 8 (HHV-8) appears to be the causative factor for the development of this neoplasm. Transplant programs are concerned about the frequencies of HHV-8 infection either in general population or transplant patients. Methods: The current study was conducted in two phases. Firstly, we detected antibodies against HHV-8 in 790 otherwise healthy blood donors. Secondly, a total of 125 kidney allograft recipients evaluated as being seropositive for HHV-8. We utilized enzyme immunoassay (EIA) for serologic studies. Results: Among blood donors, the male to female ratio was 1.05 (405 vs. 385 ) while the mean age was 38.9 ± 11.7 years. The serostatus of none of these blood donors were positive for HHV-8. Among kidney recipients, the male to female ratio was 1.9 (82 vs. 43). The mean age was 39.01 ± 14.77 years. Two (1.6%) patients were seropositive for HHV-8. Conclusion: The prevalence of HHV-8 infection among Iranians is likely to be low. Yet, owing to the evidence of this infection among kidney allograft recipients and its probable role in developing post- transplantation KS (PT-KS), further studies appear to be required to keep the various aspects of this infection under close surveillance.
