Title of article
Antioxidative Effects of Propofol vs. Ketamin in Individuals Undergoing Surgery
Author/Authors
Khoshraftar, Ebrahim hamadan university of medical sciences - Medical faculty - Department of Anesthesiology, ايران , Ranjbar, Akram hamadan university of medical sciences - School of Pharmacy - Department of Toxicology and Pharmacology, ايران , Kharkhane, Behroz hamadan university of medical sciences - Medical faculty - Department of Anesthesiology, ايران , Tavakol Heidary, Shayesteh hamadan university of medical sciences - School of Pharmacy - Department of Toxicology and Pharmacology, ايران , Gharebaghi, Zohre hamadan university of medical sciences - Medical faculty - Department of Anesthesiology, ايران , Zadkhosh, Nahid hamadan university of medical sciences - School of Pharmacy - Department of Toxicology and Pharmacology, ايران
From page
486
To page
489
Abstract
Propofol (2, 6-diisopropylphenol) is a widely used intravenous sedative-hypnotic agent for both induction/maintenance of anesthesia and sedation of critically ill patients. The present study aimed to evaluate oxidative stress biomarkers in individuals undergoing surgery with pro- pofol and ketamine at doses used to induce anesthesia. The plasma oxidative stress biomarkers such as total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol molecules (TTM) and antioxidant enzymes activity such as glutathione peroxidase (GPx), superoxid- edismutase (SOD) and catalase (CAT) were studied in blood samples obtained from 40 patients with propofol, and compared to samples from 40 patients with ketamine aged 11 - 50 years. The results showed that the ketamine group had significantly higher blood LPO level, GPx and SOD activity while having lower blood TAC and TTM concentrations in comparison to the propofol group. In conclusion, our find- ings showed that propofol has antioxidant effects in human. Further studies need to be conducted to demonstrate the exact mechanism of oxidative stress caused by anesthesia in surgery patients.
Keywords
Blood , ketamine , oxidative stress , propofol
Journal title
Archives of Iranian Medicine
Journal title
Archives of Iranian Medicine
Record number
2545387
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