Author/Authors :
Anantasika, AAN Udayana University - Medical Faculty, Sanglah Hospital - Department of obstetrics and gynecology, Fertility and Reproductive Endocrinology Division, Indonesia , Kartha, IBM Udayana University - Medical Faculty, Sanglah Hospital - Department of obstetrics and gynecology, Resident of Fertility and Reproductive Endocrinology Division, Indonesia , Suryanegara, K Udayana University - Medical Faculty, Sanglah Hospital - Department of obstetrics and gynecology, Fertility and Reproductive Endocrinology Division, Indonesia , Tunas, W Dyana Pura University - Department of Public Health, Indonesia
Abstract :
Background: The implantation rate of IVF remains low due to the adverse effect of ovarian stimulation on endometrial receptivity. Integrin β3 is the best known marker for endometrial receptivity evaluation. In this study, the impact of antagonist and agonist protocol on the expression of integrin β3 during implantation window was investigated. Methods: Two ovarian stimulation protocols were used, involving FSH plus GnRH agonist and FSH plus GnRH antagonist. Uterus sample were collected 48 hr after ovarian stimulation and the expression of integrin β3 detected by immunohistochemistry. Results: The GnRH antagonist treated mice showed significantly lower integrin β3 expression in endometrium during window of implantation than GnRH agonist treated mice. Conclusions: Antagonist protocol has more adverse impact on endometrial receptivity of mice uterus than agonist protocol
Keywords :
GnRH antagonist , endometrial receptivity , integrin β3 , ovarian stimulation
