Title of article
The Effect of Fenugreek on Nociceptive Response in Diabetic Rats
Author/Authors
Roghani, Mehrdad shahed university - School of Medicine - Department of physiology, تهران, ايران , Vaez Mahdavi, Mohammad Reza shahed university - School of Medicine - Department of physiology, تهران, ايران , Khalili, Mohsen shahed university - School of Medicine - Department of Physiology, تهران, ايران , Miri, Rohollah shahed university - School of Medicine - Department of Physiology, تهران, ايران
From page
27
To page
30
Abstract
Introduction: Diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. This study was designed to investigate the effect of Trigonella foenum-graecum (TFG) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (STZ)-induced diabetic rats. Methods: For this purpose, STZ-diabetic rats received intraperitoneal injection of aqueous leaf extract of TFG (200 mg/kg every other day for a period of one month). Results: It was found out that TFG treatment did cause a significant reduction in blood glucose in diabetic rats and TFG-treated diabetic rats exhibited a lower nociceptive score as compared to untreated-diabetic ones. Meanwhile, TFG treatment reduced the nociceptive score in both phases of the formalin test. In contrast, sodium salicylate as positive control only reduced this score in the second phase of the test. Discussion: The results suggest therapeutic potential of aqueous extract of fenugreek for treating painful diabetic neuropathy.
Keywords
Trigonella foenumgraecum , Diabetes mellitus , Pain , Rat
Journal title
Basic and Clinical Neuroscience
Journal title
Basic and Clinical Neuroscience
Record number
2548159
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