Studying uterogin drug effectiveness for acute experimental endometritis in rats

It is known that acute endometritis is accompanied by endogenous intoxication, which has a strong negative impact on the functional condition of vital organs and systems. The ability of drugs used for the treatment of endometritis to prevent the development of the inflammatory process, to reduce the degree of endogenous intoxication, and to promote the rapid normalization of the clinical status of animals is a valuable property when practicing pharmacotherapy of uterus inflammatory diseases. The aim of this study was to investigate the pharmacological activity of Uterogin drug as a therapeutic agent when used in the acute phase of the inflammatory process of reproductive system organs, and in particular, in experimental endometritis in rats. It has been established that formalin introduction into the cavity of uterine horns can simulate an acute form of endometritis. The development of experimental endometritis occurs in the background of the overall endogenous intoxication and is accompanied by a change in a number of general clinical indicators, namely suppression, decreased motor activity, disruption of the gastrointestinal tract function, increased erythrocyte sedimentation rate, decreased hemoglobin level, decreased red blood cell count, and an increase in the number of microxyphil neutrophils. The subcutaneous introduction of Uterogin in acute experimental endometritis in rats significantly reduces the inflammatory response, limits the spread of inflammation, and prevents the development of destructive and necrotic processes. The recovery of motor activity of animals is accelerated, and their clinical status is normalized. Changes in blood are less pronounced in animals to which Uterogin drug was applied twice. The anatomic and echographic studies confirm a pronounced therapeutic effect of the drug in question for acute endometritis in rats. We can draw a conclusion about the possibility of using Uterogin for clinically ill animals on the basis of the data obtained.