Author/Authors :
Hadavi, Valeh tehran university of medical sciences tums - School of Public Health and Institute of Public Health - Department of Human Genetics and Anthropology, تهران, ايران , Sanati, Mohammad H National Research Center for Genetic Engineering, ايران , Farhud, Daroush tehran university of medical sciences tums - School of Public Health and Institute of Public Health - Department of Human Genetics and Anthropology, تهران, ايران , Hushmand, Masoud National Research Center for Genetic Engineering, ايران , Hashemzadeh Chaleshtori, Morteza tehran university of medical sciences tums - School of Public Health and Institute of Public Health - Department of Human Genetics and Anthropology, تهران, ايران , Nabavi, Seyed Masoud shahed university - Department of Neurology, تهران, ايران , Younesian, Masoud tehran university of medical sciences tums - Department of Environmental Health Engineering, تهران, ايران , Seyedian, Maziar tehran university of medical sciences tums - Roozbeh Hospital, تهران, ايران
Abstract :
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The contribution of the major histocompatibility complex (MHC) has been established in numerous genetic linkage and association studies. In addition to the MHC, the chromosome 19q13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show differences in APOE allele frequencies in multiple sclerosis compared with controls, we genotyped polymorphisms in four alleles namely; ه2, ه3 and e4 alleles. This study was carried out on 81 patients with clinically definite MS and 93 asymptomatic, randomly selected elderly volunteers. A significant difference was observed in the distribution of e4 allele between patients with MS and controls (9.3% vs. 0.5%; ÷2=15.2; df=2; p 0.001). This provides strong support for the association of MS with APOE ه4 allele.
Keywords :
Multiple Sclerosis , Apolipoprotein E , Polymorphism , Iran
