Investigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia

Background: Leptin has been implicated in the differen!a!on and prolifera!on of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimula!ng factor (G- CSF), in the regula!on of early hematopoie!c stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia pa!ents. Materials and Methods: We inves!gated serum level of leptin, LIF, and IL-6 levels, body mass index, hemoglobin, and hematocrit in 30 myeloid leukemia pa!ents (15 patients with acute and 15 with chronic myeloid leukemia) before chemotherapy, and compared the results with 15 healthy controls.Results: Leptin, LIF and IL-6 serum levels, and lipid profile in myeloied leukemic pa!ent was significantly different from the control group (p 0.05). The rela!onship between leptin and BMI was sta!s!cally significant in control group, whereas in the pa!ent group, there were no significant rela!onship between leptin and BMI.Conclusion: Lipid profile and leptin, LIF, and IL-6 serum levels of leukemic patients were significantly different from normal population.