Graves Disease as the Initial Manifestation of Wegener s Granulomatosis: A Case Report

Wegener s granulomatosis is a necrotizing granulomatous vasculitis with the prevalence of 3 in 100000. Pulmonary involvement is the most common form of disease manifestation detected in 95% of cases but onset of disease with other symptoms such as proptosis and hyperthyroidism is very rare. Our patient was a 29-year-old man who had been presented to the hospital with goiter, palpitation. fatigue , and proptosis in 1997. He underwent subtotal thyroidectomy and was treated with methimazole. After six years of treatment, he admitted to the hospital for the second time with ertbritis , arthralgia, fever, hematuria and nodular pulmonary lesions. Open lung biopsy confirmed the diagnosis of wegener s granulomatosis. (Tanaffos 2006; 5(4):75-78)