Author/Authors :
Alborzi, AM tarbiat modares university - School of Medical Sciences - Department of virology, تهران, ايران , Kiani Ghalesardi, O ahvaz jundishapur university of medical sciences - Research Center of Thalassemia and Hemoglobinopathy, اهواز, ايران , Bamdad, T tarbiat modares university - School of Medical Sciences - Department of virology, تهران, ايران , Pourfathollah, AA tarbiat modares university - School of Medical Sciences - Department of Immunology, تهران, ايران , Jalalifar, MA ahvaz jundishapur university of medical sciences - Research Center of Thalassemia and Hemoglobinopathy, اهواز, ايران , Shahjahani, M tarbiat modares university - School of Medical Sciences - Department of hematology, تهران, ايران , Kazemi Arababadi, M rafsanjan university of medical sciences - Faculty of Medicine - Department of Microbiology, Hematology and Immunology, ايران , Dehghani Fard, A tarbiat modares university - School of Medical Sciences - Department of hematology, تهران, ايران , Saki, N ahvaz jundishapur university of medical sciences - Research Center of Thalassemia and Hemoglobinopathy, اهواز, ايران
Abstract :
Background: Blood transfusion plays a great role in public health and the blood safety still has remained a main concern. HBV has been considered as one of the most prevalent blood borne infections. It is estimated that chronic HBV affects 350-400 million people worldwide. Comprehensive knowledge about HBV has high importance in Iran due to high number of blood dependent patients. Material and methods: The data used in this research are derived from articles obtained by searching keywords like occult hepatitis B infection, thalassemia, hemophilia, hemodialysis, co-infection and blood transfusion in databases including PubMed, Google Scholar and Scopus. The prevalence, genotypes, HBV-HCV co-infection, HIV-HBV coinfection and their role in blood transfusion and blood safety are discussed in this review article. Results: Iran is in intermediate endemicity region and studies have reported that between 10–60% of the Iranian population has the evidence of HBV infection, with 2-7% being chronic carriers. In blood donors the rate of infection is lower than general population. The occult hepatitis B infection is the main concern in blood safety due to transmission of the HBV via seronegative blood components. Iranian researches have reported a 1- 2% prevalence of occult hepatitis B infection among Iranian blood donors. Conclusion: Based on our review findings the prevalence of HBV and occult hepatitis B infection in Iran is moderate, which shows the importance of taking necessary steps to reduce the transfer of infection via blood and its components.
Keywords :
Hepatitis B virus , prevalence , blood donor , safety
