Author/Authors :
Shahidi-Dadras, Mohammad shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران , Asadi Kani, Zahra shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران , Yousefi, Maryam shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران , Jaffari Fesharaki, Reza shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران , Abdollahimajd, Fahimeh shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران , Razavi, Mostafa shahid beheshti university of medical sciences - Skin Research Center, تهران, ايران
Abstract :
We hereby report a 79-year-old Iranian man presenting with nail dystrophy and subsequent development of purpuric and ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on the head, neck and trunk. Histological examination of the gingiva, bone marrow aspiration, and biopsy confirmed the diagnosis of primary systemic amyloidosis. In this case, nail dystrophy was the presenting sign of primary systemic amyloidosis, which is a recognized but rare manifestation of this disorder. According to this case report, we could suggest that nail dystrophy may provide a clue for early diagnosis of primary systemic amyloidosis, which would ultimately increase the survival of the patient.
Keywords :
nail dystrophy , multiple myeloma , primary presentation , systemic amyloidosis
