Title of article
EFFECT OF ELICITORS ON THE ENHANCEMENT OF PODOPHYLLOTOXIN BIOSYNTHESIS IN SUSPENSION CULTURES OF LINUM ALBUM
Author/Authors
SHAMS-ARDAKANI, MOHAMMADREZA tehran university of medical sciences tums - Faculty of Pharmacy, تهران, ايران , HEMMATI, SHIVA shiraz university of medical sciences - Faculty of Pharmacy, شيراز, ايران , MOHAGHEGHZADEH, ABDOLALI shiraz university of medical sciences - Faculty of Pharmacy, شيراز, ايران
From page
56
To page
60
Abstract
The possibility of enhancment accumulation of podophyllotoxin (PTOX) has been studied in cultures ofcell suspension of Linum album Kotschy ex Boiss. (Linaceae) producing PTOX was studied. Attemptswere made to manipulate the biosynthetic pathway of PTOX by some biotic (yeast extract) and abiotic(Ag+, Pb2+ and Cd2+) elicitors for 24 or 48 hr in Murashige and Skoog (MS) medium. Silver significantlyenhanced PTOX production up to 0.24 % (mg/g cell dry wt.) in cultures. This effect could be attributedto the inhibitory role of silver on production of ethylene.
Keywords
Linum album , Podophyllotoxin , Suspension culture , Elicitors
Journal title
Daru:Journal of Pharmaceutical Sciences
Journal title
Daru:Journal of Pharmaceutical Sciences
Record number
2551617
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