Title of article :
SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF 2-HYDROXYACETAMIDES
Author/Authors :
DARYAEE, FEREIDOON tehran university of medical sciences tums - Faculty of Pharmacy - Department of Medicinal Chemistry, تهران, ايران , KOBARFARD, FARZAD shahid beheshti university of medical sciences - Faculty of Pharmacy - Department of Medicinal Chemistry, تهران, ايران , KHALAJ, ALI tehran university of medical sciences tums - Faculty of Pharmacy - Department of Medicinal Chemistry, تهران, ايران , FARNIA, PARISSA shahid beheshti university of medical sciences - National Research Institute of Tuberculosis and Lung Diseases, تهران, ايران
Abstract :
On the basis of the structural similarity of 2-hydroxyacetamides (glycolamides) with N-glycolylmuramicacid residues of the cell wall of Mycobacterium tuberculosis several of these compounds were preparedmainly by the reaction of 5-oxo-2,2-dimethyl-1,3-dioxolane 1 (glycolic acid acetonide) with correspondingamines and their antimycobacterial activities were determined by Alamar blue Assay. Of thesynthesized compounds disubstituted amides bearing hydrophilic moieties showed moderate activity.
Keywords :
2 , Hydroxyacetamides , Glycolic acid acetonide , Alamar blue Assay , Mycobacteriumtuberculosis , Hydrophilicity
Journal title :
Daru:Journal of Pharmaceutical Sciences
Journal title :
Daru:Journal of Pharmaceutical Sciences
