Title of article :
TOXIC PYRROLIZIDINE ALKALOIDS OF ECHIUM AMOENUM FISCH. MEY.
Author/Authors :
MEHRABANI, MITRA kerman university of medical sciences - Faculty of Pharmacy - Department of Pharmacognosy, كرمان, ايران , GHANNADI, ALIREZA isfahan university of medical sciences - Isfahan Pharmaceutical Sciences Research Center, اصفهان, ايران , SAJJADI, EBRAHIM isfahan university of medical sciences - Faculty of Pharmacy - Department of Pharmacognosy, اصفهان, ايران , GHASSEMI, NASROLAH isfahan university of medical sciences - Faculty of Pharmacy - Department of Pharmacognosy, اصفهان, ايران , SHAMS-ARDAKANI, MOHAMMADREZA tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacognosy, تهران, ايران
Abstract :
Toxic pyrrolizidine alkaloids are present in some species of Echium (Boraginaceae). In this study petals of Echium amoenum Fisch. Mey. (Gol-e-Gavzaban) as a popular herbal medicine in Iran, were investigated for pyrrolizidine alkaloids (PAs). The alkaloids were separated and purified by preparative TLC and characterized by IR, one and two dimensional 1H and 13C-NMR and Mass spectroscopy. Four toxic alkaloids namely: echimidine I, echimidine isomer II, 7-angeloyl retronecine III and 7-tigloyl retronecine IV were identified.Keywords:
Keywords :
Echium amoenum , Pyrrolizidine alkaloids , Echimidine , Echimidine isomer , 7 , angeloyl retronecine , 7 , tigloyl retronecine
Journal title :
Daru:Journal of Pharmaceutical Sciences
Journal title :
Daru:Journal of Pharmaceutical Sciences
